2

Association of clinical covariates with likelihood of detection by 68Ga PSMA-PET/CT

VariableOdds ratio (95% CI)P
pT-category
 pT3a vs. pT2 (reference) 1.91 (0.48–8.87)0.362
 pT3b vs. pT2 (reference) 1.33 (0.32–4.99)0.670
pN-category
 pN1 vs. pN0 (reference) 2.10 (0.28–43.4)0.524
Margin status
 Positive vs. negative (reference) 1.58 (0.42–6.24)0.5
Gleason score
 8-9 (ISUP G4-5) vs. 5-7
 (ISUP G1-3; reference)
0.70 (0.24–2.07)0.499
Duration between RadP to BCR
 Continuous
 (per month increase)
1.01 (0.99–1.06)0.395
 ≤ 6 vs. > 6 (month; reference) 1.13 (0.26–5.16)0.868
PSA at time of 68Ga
PSMA-PET/CT
 Continuous
 (per 0.1 ng/ml increase)
1.134 (1.046–1.299)0.017*
 > 1.0 vs. ≤ 1.0
 (ng/mL; reference)
10.84 (3.03–88.4)0.002*
PSA doubling time
 Continuous
  (per month increase)
0.974 (0.923–1.04)0.362
 ≤ 9 vs. > 9
  (month; reference)
0.336 (0.036–1.917)0.232

ISUP, International Society for Urological Pathology grading system for prostate cancer based on Gleason score; RadP, radical prostatectomy; BCR, biochemical relapse; PSA, prostate specific antigen. *Significant associations highlighted in bold italics.