The toxicity profile of the two groups
| Item | The control group (n = 272) | The endostatin group (n = 58) | P | |||||||
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |||
| Leukopenia | 137 | 87 | 28 | 1 | 30 | 16 | 4 | 0 | 0.451 | |
| lower hemoglobin | 121 | 89 | 14 | 0 | 22 | 15 | 3 | 0 | 0.169 | |
| Thrombocytopenia | 13 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0.900 | |
| Nausea and vomiting | 24 | 217 | 31 | 0 | 6 | 47 | 5 | 0 | 0.784 | |
| Oral mucositis | 161 | 65 | 6 | 0 | 38 | 13 | 1 | 0 | 0.774 | |
| Hepatic injury | 14 | 86 | 141 | 9 | 2 | 20 | 32 | 2 | 0.695 | |
| Renal injury | 11 | 5 | 0 | 0 | 2 | 2 | 0 | 0 | 0.755 | |