Demographic and clinical characteristics of all participants in the three phases of the study
| Variables | Profiling phase (No., %) | Validation phase (No., %) | Diagnostic phase (No., %) | |||
|---|---|---|---|---|---|---|
| NSCLC (n = 8) | OLs & HPs (n = 8) | NSCLC (n = 25) | OLs & HPs (n = 49) | NSCLC (n = 117) | OLs (n = 113) | |
| Age (Mean±SD) | 66.7±2.3 | 66.7±2.3 | 59.9±3.1 | 61.9±1.7 | 64.3±12.1 | 57.8±14.0 |
| Gender | ||||||
| Male | 4 (50.0) | 4 (50.0) | 14 (56.0) | 27 (55.1) | 74 (63.2) | 59 (52.2) |
| Female | 4 (50.0) | 4 (50.0) | 11 (44.0) | 22 (44.9) | 43 (36.8) | 54 (47.8) |
| Smoking status | ||||||
| Non-smoker | 5 (62.5) | 5 (62.5) | 15 (60.0) | 23 (46.9) | 48 (41.0) | 69 (61.1)* |
| Smoker | 3 (37.5) | 3 (37.5) | 10 (40.0) | 26 (53.1) | 69 (59.0) | 44 (38.9) |
| Alcohol drinking | ||||||
| Non-drinker | 6 (75.0) | 4 (50.0) | 18 (72.0) | 24 (49.0) | 69 (59.0) | 68 (60.2) |
| Drinker | 2 (25.0) | 4 (50.0) | 7 (28.0) | 25 (51.0) | 48 (41.0) | 45 (39.8) |
| Family history of cancer | ||||||
| No | 6 (75.0) | 6 (75.0) | 17 (68.0) | 42 (85.7) | 80 (68.4) | 76 (67.3) |
| Yes | 2 (25.0) | 2 (25.0) | 8 (32.0) | 7 (14.3) | 37 (31.6) | 37 (32.7) |
| Histological type | ||||||
| ADC | 6 (75.0) | 22 (88.0) | 79 (67.5) | |||
| SCC | 2 (25.0) | 3 (12.0) | 22 (18.8) | |||
| US-NSCLC | – | – | 16 (13.7) | |||
| TNM stage | ||||||
| I | 1 (12.5) | 1 (4.0) | 9 (7.7) | |||
| II | – | 1 (4.0) | 5 (4.3) | |||
| III | – | – | 13 (11.1) | |||
| IV | 7 (87.5) | 23 (92.0) | 90 (76.9) | |||
*P value < 0.05. ADC, adenocarcinoma; HPs, healthy persons; NSCLC, non-small cell lung cancer; OLs, other lung diseases; SCC, squamous cell carcinoma; SD, standard deviation; US-NSCLC, unspecified non-small cell lung cancer.