Table 2

Cox analyses of risk factors associated with OS

Variables (OS)		Univariate analysis			Multivariate analysis
Variables (OS)		HR	95% CI	P	HR	95% CI	P
Cholecystectomy	No	1.207	0.781–1.864	0.397	1.160	0.730–1.843	0.530
Cholecystectomy	Yes	1.207	0.781–1.864	0.397	1.160	0.730–1.843	0.530
Age (years)	<60	1.678	1.089–2.585	0.010*	1.788	1.130–2.829	0.013*
Age (years)	≥60	1.678	1.089–2.585	0.010*	1.788	1.130–2.829	0.013*
Sex	Female	1.350	0.733–2.486	0.335	1.575	0.808–3.073	0.182
Sex	Male	1.350	0.733–2.486	0.335	1.575	0.808–3.073	0.182
Max D (cm)		1.011	0.807–1.268	0.922	1.419	0.962–1.967	0.519
Number	1	1.000	–	–	1.000	–	–
	2	2.261	1.426–3.587	<0.001*	3.010	1.658–5.463	<0.001*
	3	2.590	1.369–4.900	0.003*	5.981	2.556–13.997	<0.001*
Cirrhosis	No	1.000	–	–	1.000	–	–
	HBV	0.552	0.283–1.076	0.081	0.558	0.275–1.132	0.106
	HCV	0.740	0.300–1.824	0.513	0.637	0.228–1.775	0.388
	AH	–	–	–	–	–	–
Child-Pugh class	A	2.318	1.158–4.637	0.018*	2.001	0.907–4.414	0.086
Child-Pugh class	B	2.318	1.158–4.637	0.018*	2.001	0.907–4.414	0.086
AFP (ng/mL)	<20	1.128	0.736–1.729	0.581	0.990	0.613–1.599	0.967
AFP (ng/mL)	≥20	1.128	0.736–1.729	0.581	0.990	0.613–1.599	0.967
AST (U/L)		1.004	0.993–1.015	0.487	1.008	0.987–1.030	0.450
ALT (U/L)		0.999	0.988–1.011	0.891	0.992	0.974–1.010	0.399
γ-GT (U/L)		1.003	0.999–1.006	0.137	1.000	0.996–1.005	0.936
ALB		1.001	0.959–1.044	0.971	1.019	0.968–1.072	0.478
TBIL		0.994	0.970–1.019	0.636	0.985	0.956–1.014	0.307
CRE		0.999	0.995–1.004	0.810	0.998	0.991–1.004	0.482
PLT		0.999	0.995–1.003	0.490	0.999	0.994–1.004	0.611
INR		1.009	0.977–1.041	0.585	1.007	0.972–1.042	0.716
NEUT		6.520	1.077–39.481	0.041	0.881	0.009–86.150	0.957
LYMPH		0.074	0.009–0.625	0.017*	0.037	0.000–6.343	0.209

*P < 0.05.