Pharmacokinetic parameters in rats after intravenous administration of PEG-Lipo-β-E and elemene injection
| Parameters | Units | Elemene injection | PEG-Lipo-β-E |
|---|---|---|---|
| AUC(0-t) | mg/L*min | 69.951 ± 14.118* | 123.331 ± 3.265* |
| MRT(0-t) | min | 17.175 ± 1.591 | 15.989 ± 0.599 |
| T1/2z | min | 15.964 ± 1.938* | 25.850 ± 0.609* |
| Vz | L/kg | 0.428 ± 0.219 | 0.258 ± 0.046 |
| CLz | L/min/kg | 0.014 ± 0.003* | 0.008 ± 0.000* |
The data are represented as the mean ± SD (n = 5). AUC, area under the concentration-time curve; MRT, mean residence time; T1/2z, half-life; Vz, steady-state apparent volume of distribution; CLz, clearance. *P < 0.05 was considered statistically significant.