Table 3

Cox analyses of risk factors associated with DFS

Variables (DFS)		Univariate analysis			Multivariate analysis
Variables (DFS)		HR	95% CI	P	HR	95% CI	P
Cholecystectomy	No	1.367	1.036–1.804	0.027*	1.364	1.023–1.819	0.035*
Cholecystectomy	Yes	1.367	1.036–1.804	0.027*	1.364	1.023–1.819	0.035*
Age (years)	<60	1.306	0.998–1.711	0.052	1.237	0.929–1.646	0.146
Age (years)	≥60	1.306	0.998–1.711	0.052	1.237	0.929–1.646	0.146
Sex	Female	1.486	1.015–2.176	0.041*	1.365	0.910–2.046	0.132
Sex	Male	1.486	1.015–2.176	0.041*	1.365	0.910–2.046	0.132
Max D (cm)		0.962	0.835–1.109	0.595	1.261	0.859–1.503	0.509
Number	1	1.000	–	–	1.000	–	–
	2	2.332	1.745–3.118	<0.001*	2.744	1.925–3.912	<0.001*
	3	2.522	1.647–3.862	<0.001*	3.411	2.021–5.759	<0.001*
Cirrhosis	No	1.000	–	–	1.000	–	–
	HBV	1.337	0.789–2.266	0.286	1.313	0.755–2.285	0.335
	HCV	1.825	0.940–3.543	0.075	1.511	0.730–3.126	0.266
	AH	–	–	–	–	–	–
Child-Pugh class	A	1.145	0.639–2.051	0.649	1.000	0.514–1.945	0.999
Child-Pugh class	B	1.145	0.639–2.051	0.649	1.000	0.514–1.945	0.999
AFP (ng/mL)	<20	1.203	0.916–1.579	0.183	1.147	0.854–1.540	0.362
AFP (ng/mL)	≥20	1.203	0.916–1.579	0.183	1.147	0.854–1.540	0.362
AST (U/L)		1.000	0.992–1.008	0.991	1.001	0.987–1.014	0.930
ALT (U/L)		1.000	0.993–1.007	0.893	0.992	0.981–1.004	0.183
γ-GT (U/L)		1.004	1.002–1.006	<0.001*	1.003	1.000–1.006	0.024*
ALB		1.026	0.997–1.055	0.183	1.016	0.979–1.054	0.397
TBIL		0.989	0.973–1.006	0.205	0.991	0.972–1.011	0.384
CRE		1.002	1.000–1.004	0.012*	1.001	1.000–1.003	0.118
PLT		0.999	0.996–1.001	0.247	0.998	0.995–1.001	0.277
INR		0.485	0.191–1.231	0.128	0.684	0.164–2.856	0.602
NEUT		1.519	0.421–5.4884	0.524	1.287	0.066–25.185	0.868
LYMPH		0.555	0.135–2.280	0.414	0.431	0.020–9.203	0.590

*P < 0.05.