Overview of mRNAs as competing endogenous RNAs in lung cancer
| CeRNA | Target miRNA | mRNA | Expression | Key factors and pathways | Biological functions | Tumor types | CeRNA role | References |
|---|---|---|---|---|---|---|---|---|
| AEG-1 | MiR-30a | Vimentin/N-cadherin/Snail/E-cadherin | Upregulatede | EMT, TGF-β and TNF-α | Migration and invasion | NSCLC | Oncogene | 119 |
| PCNX | MiR-26/182/340/506 | Skp2 | Upregulatede | EGF-induced Pakt | Growth, proliferation and apoptosis | Lung cancer | Oncogene | 120 |
| ZEB1 | MiR-181b | ITGA1, AC9 | Upregulatede | ITGA1 and AC9 | Migration and metastasis | LUAD | Oncogene | 121 |
| HMGA2 | Let-7 | Tgfbr3 | Upregulatede | TGF-β signalling | Growth, invasion | NSCLC | Oncogene | 14 |
| FOXO1 | MiR-96 | DUSP1 | Upregulatede | EGFR/EGF signaling pathway, MMP2 and MMP11 | Growth, proliferation, migration and invasion | NSCLC | Oncogene | 122 |
–: not reported.