Table 2

Overview of circular (circ)RNAs as competing endogenous RNAs in lung cancer

CeRNA	Target MiRNA	mRNA	Expression	Key factors and pathways	Biological functions	Tumor types	CeRNA role	References
Circ_0020123	MiR-488-3p	ADAM9	Upregulated	–	Apoptosis, migration and invasion	NSCLC	Oncogene	⁹⁸
Circ-FOXM1	MiR-1304-5p	PPDPF, MACC1	Upregulated	–	Proliferation, migration, invasion and apoptosis	NSCLC	Oncogene	⁹⁹
CircHIPK3	MIR124-3p	STK11	Upregulated	MIR124-3p-STAT3-PRKAA/AMPKα	Proliferation, migration, invasion	NSCLC	Oncogene	¹⁰⁰
CircTP63	MiR-873-3p	FOXM1	Upregulated	FOXM1, CENPA and CENPB	Proliferation, growth	LUSC	Oncogene	¹⁰¹
VANGL1	MiR-195	Bcl-2	Upregulated	Bcl-2 and Bax	Proliferation, apoptosis, migration and invasion	NSCLC	Oncogene	¹⁰²
Circ_0003645	MiR-1179	TMEM14A	Upregulated	–	Migration, invasion, growth, apoptosis	NSCLC	Oncogene	¹⁰³
Circ-ENO1	MiR-22-3p	ENO1	Upregulated	Cleaved-caspase 3/6/9/PARP, EMT	Migration, invasion, apoptosis, growth	LUAD	Oncogene	¹⁰⁴
CircPTK2	MiR-429/200b-3p	TIF1γ	Downregulated	TGFB1/Smad, EMT	Metastasis, migration, invasion	NSCLC	Suppressor	¹⁰⁵
CircRNA100146	MiR-361-3p/615-5p	SF3	Upregulated	PCNA, p53, NFAT5, COL1A1, TRAF3	Proliferation, apoptosis, growth, invasion	NSCLC	Oncogene	¹⁰⁶
CircPVT1	MiR-497	Bcl-2	Upregulated	Bcl-2 and Bax	Proliferation, apoptosis, growth	NSCLC	Oncogene	¹⁰⁷
CircPVT1	MiR-125b	E2F2	Upregulated	E2F2 Signaling, cyclin D, Rb, c-Fos	Proliferation, apoptosis, migration and invasion	NSCLC	Oncogene	¹⁰⁸
HOXA11-AS	MiR-124	Sp1	Upregulated	Ecadherin, vimentin, β-catenin, Snail and Slug	Proliferation, invasion	NSCLC	Oncogene	¹⁰⁹
Circ_0074027	MiR-185-3p	BRD4/MADD	Upregulated	BRD4 and MADD	Proliferation, apoptosis, migration and invasion	NSCLC	Oncogene	¹¹⁰
Circ-CMPK1	MiR-302e	Cyclin D1	Upregulated	Cyclin D1	Proliferation	NSCLC	Oncogene	¹¹¹
CESRP1	MiR-93-5p	Smad7/p21	Downregulated	P21, p-Smad2/3, Smad4 and Smad7	Migration and invasion	SCLC	Suppressor	¹¹²
CircARHGAP10	MiR-150-5p	GLUT1	Upregulated	E-cadherin, N-cadherin and Snail	Proliferation, migration	NSCLC	Oncogene	¹¹³