GFRα-1/RET positive patients have a high risk of recurrence
| Gene | Total | IHC positive (+), IHC negative (–) | ||||||
|---|---|---|---|---|---|---|---|---|
| GFRα-1 | + | + | – | – | ||||
| RET | + | – | P* | + | P** | – | P*** | |
| Cases, n (%) | 51 | 19 (37.3) | 13 (25.5) | – | 9 (17.6) | – | 10 (19.6) | – |
| PNI, n (%) | <0.001 | <0.001 | <0.001 | |||||
| Positive | 19 | 17 (89.5) | 2 (15.4) | 0 (0.0) | 0 (0.0) | |||
| Negative | 32 | 2 (10.5) | 11 (84.6) | 9 (100.0) | 10 (100.0) | |||
| Recurrence, n (%) | 0.004 | 0.003 | 0.032 | |||||
| Yes | 26 | 16 (84.2) | 4 (30.8) | 2 (22.2) | 4 (40.0) | |||
| No | 25 | 3 (15.8) | 9 (69.2) | 7 (77.8) | 6 (60.0) | |||
| Pain, n (%) | 0.21 | 0.04 | 0.07 | |||||
| Yes | 31 | 13 (68.4) | 6 (46.2) | 2 (22.2) | 10 (100.0) | |||
| No | 20 | 6 (31.6) | 7 (53.8) | 7 (77.8) | 0 (0.0) | |||
GDNF, glial-derived neurotrophic factor; GFRα-1, GDNF family receptor α-1; RET, Ret receptor of tyrosine kinase; PNI, perineural invasion; IHC, immunohistochemistry. P*, GFRα-1(+)/RET (+) vs. GFRα-1(+)/RET (–); P**, GFRα-1(+)/RET (+) vs. GFRα-1(–)/RET (+); P***, GFRα-1(+)/RET (+) vs. GFRα-1(–)/RET (–).