Comparison of characteristics of IDH-mutant GBM samples with or without MGMT methylation (cutoff ≥30%) in cohort A
| Unmethylated (n = 35) | Methylated (n = 15) | P | |||
|---|---|---|---|---|---|
| Median age (range) | 41 (26–63) | 39 (33–62) | 0.4529a | ||
| Gender | 0.2077b | ||||
| Male | 23 | 65.7% | 7 | 46.7% | |
| Female | 12 | 34.3% | 8 | 53.3% | |
| Type | 0.1935b | ||||
| Primary | 14 | 40.0% | 9 | 60.0% | |
| Recurrent | 21 | 60.0% | 6 | 40.0% | |
| Resection | 0.1053b | ||||
| Gross total | 26 | 74.3% | 8 | 53.3% | |
| Subtotal | 8 | 22.9% | 7 | 46.7% | |
| Unknown | 1 | 2.9% | 0 | 0.0% | |
| TMZ cycles | 0.9706b | ||||
| ≥3 and <6 | 9 | 25.7% | 4 | 26.7% | |
| ≥6 | 30 | 85.7% | 13 | 86.7% | |
| KPS | 0.6479b | ||||
| <70 | 12 | 34.3% | 5 | 33.3% | |
| ≥70 | 14 | 40.0% | 8 | 53.3% | |
| Unknown | 9 | 25.7% | 2 | 13.3% | |
| Median PFS (months) | 9.33 | 26.04 | 0.0012c | ||
| Median OS (months) | 13.1 | 35.8 | 0.0004c | ||
aCalculated by the nonparametric test; bCalculated by the chi-square test; cCalculated by the log-rank test in Kaplan-Meier curves.