Associations of TMEM88 methylation and expression with patient clinical and pathological features

Characteristics	Group	Methylation					Expression
Characteristics	Group	n	Low n (%)	High n (%)	χ²	P	n	Low n (%)	High n (%)	χ²	P
Age (years)	≤ 60	213	56 (54)	47 (46)	1.364	0.243	201	50 (51)	48 (49)	0.046	0.831
Age (years)	> 60	213	51 (46)	59 (54)	1.364	0.243	201	51 (50)	52 (50)	0.046	0.831
Stage	I-II	208	74 (53)	65 (47)	0.868	0.351	197	58 (48)	64 (52)	0.943	0.331
Stage	III-IV	208	32 (46)	37 (54)	0.868	0.351	197	41 (55)	34 (45)	0.943	0.331
BMI	≤ 24	212	59 (52)	55 (48)	0.162	0.687	199	48 (49)	51 (51)	0.126	0.723
BMI	> 24	212	48 (49)	50 (51)	0.162	0.687	199	51 (51)	49 (49)	0.126	0.723
Gender	Male	213	58 (47)	66 (53)	1.422	0.233	201	65 (52)	61 (48)	0.242	0.623
Gender	Female	213	49 (55)	40 (45)	1.422	0.233	201	36 (48)	39 (52)	0.242	0.623
History of lung diseases	No	213	97 (50)	98 (50)	0.223	0.637	201	94 (51)	91 (49)	0.294	0.588
History of lung diseases	Yes	213	10 (56)	8 (44)	0.223	0.637	201	7 (44)	9 (56)	0.294	0.588
Family history	No	212	90 (51)	88 (49)	0.004	0.952	200	81 (50)	81 (50)	0.085	0.770
Family history	Yes	212	17 (50)	17 (50)	0.004	0.952	200	20 (53)	18 (47)	0.085	0.770
Smoking status	No	213	43 (57)	33 (43)	1.902	0.168	201	25 (42)	34 (58)	2.072	0.150
Smoking status	Yes	213	64 (47)	73 (53)	1.902	0.168	201	76 (54)	66 (46)	2.072	0.150
Histology	LUSC	185	40 (42)	55 (58)	6.683	0.010	167	52 (53)	47 (47)	0.776	0.378
Histology	LUAD	185	55 (61)	35 (39)	6.683	0.010	167	31 (46)	37 (54)	0.776	0.378
Tumor size (cm)	< 3	212	46 (66)	24 (34)	9.713	0.002	200	30 (52)	28 (48)	0.097	0.755
Tumor size (cm)	≥ 3	212	61 (43)	81 (57)	9.713	0.002	200	70 (49)	72 (51)	0.097	0.755