Genotype and allele of ApaI, VDR-polymorphism, and BsmI-ApaI, ApaI-TaqI, BsmI-ApaI-TaqI combined genotypes of 74 melanoma patients and comparisons between groups of 100% VDR-positive cells (n=12) vs. <100% (n=62); over the median (>20%) VDRpositive cells (n=36) vs. below or equal the median (≤20%) (n=38); and absence of VDR-positive cell (n=15) vs. remaining cases with detected VDR expression (n=59)
| VDR genotype or combined genotype | All melanoma patients (n=74) | 100% VDR-positive cells (n=12) | <100% VDR-positive cells (n=62) | P=100% vs.<100% VDR-positive | >20%a VDR-positive cells (n=36) | ≤20% VDR-positive cells (n=38) | P > 20% vs. ≤20% VDR-positive | VDR absence (0% positive) (n=15) | VDR presence (>0% positive) (n=59) | PVDR absence vs. presence |
|---|---|---|---|---|---|---|---|---|---|---|
| ApaI genotype | ||||||||||
| AA | 30 (40.5) | 8 (66.7) | 22 (35.5) | 0.058 | 13 (36.1) | 17 (44.7) | 0.450 | 8 (53.3) | 22 (37.3) | 0.258 |
| Aa | 36 (48.6) | 4 (33.3) | 32 (51.6) | 0.246 | 22 (61.1) | 14 (36.8) | 0.037 | 5 (33.3) | 31 (52.5) | 0.184 |
| aa | 8 (10.8) | 0 (–) | 8 (12.9) | 0.339 | 1 (2.8) | 7 (18.4) | 0.056 | 2 (13.3) | 6 (10.2) | 0.660 |
| A allele | 96/148 (64.9) | 20/24 (83.3) | 76/124 (61.3) | 0.038 | 48/72 (66.7) | 48/76 (63.2) | 0.655 | 21/30 (70.0) | 75/118 (63.6) | 0.509 |
| a allele | 52/148 (35.1) | 4/24 (16.7) | 48/124 (38.7) | 0.038 | 24/72 (33.3) | 28/76 (36.8) | 0.655 | 9/30 (30.0) | 43/118 (36.4) | 0.509 |
| BsmI-ApaI combined genotype | ||||||||||
| BBAA | 23 (31.1) | 5 (41.7) | 18 (29.0) | 0.498 | 9 (25.0) | 14 (36.8) | 0.271 | 6 (40.0) | 17 (28.8) | 0.533 |
| BbAA | 5 (6.8) | 3 (25.0) | 2 (3.2) | 0.028 | 4 (11.1) | 1 (2.6) | 0.194 | 1 (6.7) | 4 (6.8) | 1.000 |
| BbAa | 31 (41.9) | 1 (8.3) | 30 (48.4) | 0.010 | 18 (50.0) | 13 (34.2) | 0.169 | 5 (33.3) | 26 (44.1) | 0.452 |
| Bbaa | 2 (2.7) | 0 (–) | 2 (3.2) | 1.000 | 0 (–) | 2 (5.3) | 0.494 | 0 (–) | 2 (3.4) | 1.000 |
| bbAA | 2 (2.7) | 0 (–) | 2 (3.2) | 1.000 | 0 (–) | 2 (5.3) | 0.494 | 1 (6.7) | 1 (1.7) | 0.367 |
| bbAa | 5 (6.8) | 3 (25.0) | 2 (3.2) | 0.028 | 4 (11.1) | 1 (2.6) | 0.194 | 0 (–) | 5 (8.5) | 0.576 |
| bbaa | 6 (8.1) | 0 (–) | 6 (9.7) | 0.581 | 1 (2.8) | 5 (13.2) | 0.200 | 2 (13.3) | 4 (6.8) | 0.595 |
| ApaI-TaqI combined genotype | ||||||||||
| AATT | 4 (5.4) | 0 (–) | 4 (6.5) | 1.000 | 0 (–) | 4 (10.5) | 0.115 | 3 (20.0) | 1 (1.7) | 0.025 |
| AATt | 14 (18.9) | 6 (50.0) | 8 (12.9) | 0.008 | 9 (25.0) | 5 (13.2) | 0.194 | 4 (26.7) | 10 (16.9) | 0.463 |
| AAtt | 12 (16.2) | 2 (16.7) | 10 (16.1) | 1.000 | 4 (11.1) | 8 (21.1) | 0.246 | 1 (6.7) | 11 (18.6) | 0.439 |
| AaTT | 12 (16.2) | 3 (25.0) | 9 (14.5) | 0.399 | 9 (25.0) | 3 (7.9) | 0.046 | 1 (6.7) | 11 (18.6) | 0.439 |
| AaTt | 24 (32.4) | 1 (8.3) | 23 (37.1) | 0.089 | 13 (36.1) | 11 (28.9) | 0.511 | 4 (26.7) | 20 (33.9) | 0.761 |
| aaTT | 8 (10.8) | 0 (–) | 8 (12.9) | 0.339 | 1 (2.8) | 7 (18.4) | 0.056 | 2 (13.3) | 6 (10.2) | 0.660 |
| BsmI-ApaI-TaqI combined genotype | ||||||||||
| BBAATT | 1 (1.4) | 0 (–) | 1 (1.6) | 1.000 | 0 (–) | 1 (2.6) | 1.000 | 1 (6.7) | 0 (–) | 0.203 |
| BBAATt | 10 (13.5) | 3 (25.0) | 7 (11.3) | 0.351 | 5 (13.9) | 5 (13.2) | 1.000 | 4 (26.7) | 6 (10.2) | 0.110 |
| BBAAtt | 12 (16.2) | 2 (16.7) | 10 (16.1) | 1.000 | 4 (11.1) | 8 (21.1) | 0.246 | 1 (6.7) | 11 (18.6) | 0.439 |
| BbAATt | 4 (5.4) | 3 (25.0) | 1 (1.6) | 0.012 | 4 (11.1) | 0 (–) | 0.051 | 0 (–) | 4 (6.8) | 0.576 |
| BbAATT | 1 (1.4) | 0 (–) | 1 (1.6) | 1.000 | 0 (–) | 1 (2.6) | 1.000 | 1 (6.7) | 0 (–) | 0.203 |
| BbAaTT | 7 (9.5) | 0 (–) | 7 (11.3) | 0.590 | 5 (13.9) | 2 (5.3) | 0.255 | 1 (6.7) | 6 (10.2) | 1.000 |
| BbAaTt | 24 (32.4) | 1 (8.3) | 23 (37.1) | 0.089 | 13 (36.1) | 11 (28.9) | 0.511 | 4 (26.7) | 20 (33.9) | 0.761 |
| BbaaTT | 2 (2.7) | 0 (–) | 2 (3.2) | 1.000 | 0 (–) | 2 (5.3) | 0.494 | 0 (–) | 2 (3.4) | 1.000 |
| bbAATT | 2 (2.7) | 0 (–) | 2 (3.2) | 1.000 | 0 (–) | 2 (5.3) | 0.494 | 1 (6.7) | 1 (1.7) | 0.367 |
| bbAaTT | 5 (6.8) | 3 (25.0) | 2 (3.2) | 0.028 | 4 (11.1) | 1 (2.6) | 0.194 | 0 (–) | 5 (8.5) | 0.576 |
| bbaaTT | 6 (8.1) | 0 (–) | 6 (9.7) | 0.581 | 1 (2.8) | 5 (13.2) | 0.200 | 2 (13.3) | 4 (6.8) | 0.595 |
aOver the median value of percentage (%) of cells positive for VDR protein.