1

Main characteristics of the 19 patient series found.

AuthorCountry and yearPatients, n (% with liver metastases) OS (months)OS with no history of HM (months)OS with history of HM (months)Variables affecting survival
Perera NKAustralia 201366 (24.0)At 5 years 39.6%Not reportedNot reportedNone
Kamiyoshihara MJapan 201473 (37.0)At 5 years 70%, 33.7 mAt 5 years 59.5%, 39.5 mCEA level, number of metastases, female
Renaud SFrance 2013320 (15.0)74 m (60–87)47 m (21–76)Lymph node involvement, Liver metastases
Matsui TJapan 2013186 (13.4)At 5 years 63%At 5 years 54%, 60 m
Javed MAUK 201466 (39.0)45 m43 m33 mASA class, Metastasis size
Cho SKorea 201384 (26.2)31 m45.1 m26.3 mAge, Number of metastases, DFS, CEA
Iida TJapan 20131223 (18.8)69.5 mAt 5 years 55.3%, 75.7 mAt 5 years 44.6% 49.4 mAge, Number of metastases, Metastasis size
Hattori NJapan 201396 (30.2)At 5 years 61.3%At 5 years 69%At 5 years 43%Lymph node involvement, Liver metastases, DFS
Jarabo JRSpain 201179 (27.8)At 5 years 53.3%At 5 years 50.1%At 5 years 62.5%Age, CEA level, Lymph node involvement
Zabaleta JSpain 201190 (18.7)84 m89.2 m (74.1–104.2)58.8 m (34.4–83.1)DFI, Age, Lymph node involvement, Early recurrence, Metastasis size, History of liver metastases
Borano PItaly 2011137 (31.4)At 5 years 55.4%HR 0.919Number of metastases, DFS
Chen FJapan 201175 (25.3)At 5 years 59.7%Not reportedNot reported
Suemitsu RJapan 201157 (56.1)53.9% 65.2 mAt 5 years 71.5%At 5 years 43.1%TNM stage of primary tumour
Hwang MRKorea 2010125 (29.6)At 5 years 58%At 5 years 13.7%Early recurrence, Non-pulmonary metastasis, CEA level, Lymph node involvement
Landes USwitzerland 201040 (60.0)87 m, at At 5 years 53.8%40 m At 5 years 29.2%Liver metastasis
Riquet MFrance 2010127 (24.4)At 5 years 41%At 5 years 39.2%At 5 years 53.3%Vascular invasion
Watanabe KJapan 2009122 (29.2)At 5 years 67.8%Not reportedNot reportedCEA level, Lymph node involvement
Lin BRTaiwan 200963 (23.8)At 5 years 43.9%At 5 years 26.8%At 5 years 45.9%Surgical approach, Liver metastasis, DFS

OS: overall survival; HM: hepatic metastasectomy; CEA: carcinoembryonic antigen; DFS: disease-free survival