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Effect of anti-diabetic drugs on colon carcinogenesis in rodents

Species, strain	Sex	Carcinogenic agent	Drug	Doses	Route	Effect	Reference
BALB/c mice	Male & Female	AOM	MF	250 mg/kg	Diet	Inhibition	³⁰
BALB/c mice	Male & Female	AOM	MF	250 mg/kg	d.w.	Inhibition	³¹
BALB/c mice	Male & Female	AOM	MF	250 mg/kg	i.p.	Inhibition	³¹
BALB/c mice	Male	AOM	MF	250 mg/kg	i.p.	Inhibition	²⁵
BALB/c mice	Female	DMH	MF	250 mg/kg	i.p.	Inhibition	²⁰
Swiss albino mice	Male	DMH	MF	100–200 mg/kg	Oral	Inhibition	³²
ICR mice	Male	DMH+DSS	MF	240 mg/kg	Oral	Inhibition	¹³
F344 rats	Male	AOM	MF	15 mg/kg	d.w.	Inhibition	²⁷
F344 rats	ND	AOM	MF	500–1000 ppm	Diet	No effect	³³
F344 rats	ND	AOM	MF	1000 ppm	Diet	No effect	³⁴
LIO rats	Female	DMH	PF	5 mg/rat	Oral	Inhibition	³⁵
LIO rats	Female	DMH	Diabenol	0.1 mg/ml	d.w.	Inhibition	³⁶
SD rats	Male	DMH	MF	150 mg/kg	Oral	Inhibition	¹²
Wistar rats	Male	DMH	MF	40–360 mg/kg	Oral	Inhibition	¹³

AOM: azoxymethane; DMH: 1,2-dimethylhydrazine; DSS: dextran sodium sulfate. d.w.: drinking water; i.p.: intreperitoneally; ppm: parts per million.