Univariate and multivariate Cox regression analysis for overall survival in patients with LSCC
| Factors | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age | 1.658 (1.184-2.321) | 0.003 | 1.854 (1.297-2.650) | 0.001 | |
| Gender | 0.540 (0.172-1.695) | 0.291 | |||
| Smoking | 0.821 (0.547-1.231) | 0.340 | |||
| Alcohol | 1.247 (0.953-1.633) | 0.108 | |||
| T stage | |||||
| T1 | Ref | Ref | |||
| T2 | 2.862 (1.723-4.574) | <0.001 | 1.852 (1.060-3.233) | 0.030 | |
| T3 | 4.881 (2.953-8.069) | <0.001 | 2.535 (1.442-4.454) | 0.001 | |
| T4a+T4b | 6.207 (3.761-10.244) | <0.001 | 2.842 (1.585-5.096) | <0.001 | |
| N stage | |||||
| N0 | Ref | Ref | |||
| N1 | 4.183 (2.683-6.523) | <0.001 | 2.077 (1.269-3.401) | 0.004 | |
| N2a+N2b+N2c | 4.681 (3.130-7.003) | <0.001 | 2.088 (1.263-3.452) | 0.004 | |
| N3 | 25.230 (11.173-56.972) | <0.001 | 7.659 (2.919-20.102) | <0.001 | |
| Pathology grade | |||||
| Well | Ref | Ref | |||
| Moderate | 2.060 (1.430-2.969) | <0.001 | 1.497 (1.010-2.219) | 0.044 | |
| Poor | 4.133 (2.564-6.661) | <0.001 | 1.791 (1.047-3.064) | 0.033 | |
| Tumor location | 0.562 (0.401-0.787) | 0.001 | 1.197 (0.847-1.691) | 0.308 | |
| Treatment | 1.540 (1.407-1.687) | <0.001 | 1.259 (1.123-1.413) | <0.001 | |
| BMI | 1.964 (1.616-2.388) | <0.001 | 1.747 (1.433-2.130) | <0.001 | |
LSCC, laryngeal squamous cell carcinoma; BMI, body mass index.