1

Characteristics of the study population

CharacteristicsTotal (n=1,122)PET (n=242)Surgery (n=880)P
Age (years)<0.0001
 ≥70-7422 (5.5%)381 (94.5%)
 ≥75-7952 (16.1%)271 (83.9%)
 ≥80-8465 (30.8%)146 (69.2%)
 ≥85-9062 (48.4%)66 (51.6%)
 ≥>9041 (71.9%)16 (28.1%)
 Median (range)84 (70-101)76 (70-94)
Tumour grade0.953
 ≥146 (21.7%)166 (78.3%)
 ≥2144 (22.0%)510 (88.0%)
 ≥331 (19.4%)129 (80.6%)
 Missing21 (21.9%)75 (78.1%)
HER2 status0.0042
 Positive/borderline17 (12.5%)119 (87.5%)
 Negative158 (20.9%)597 (79.1%)
 Missing67 (29.0%)164 (71.0%)
Nodal status0.0194
 Positive51 (28.3%)129 (71.7%)
 Negative183 (20.0%)734 (80.0%)
 Missing8 (32.0%)17 (68.0%)
Tumour size<0.0001
 ≥<10 mm15 (12.6%)104 (87.4%)
 ≥10-19.9 mm64 (17.0%)312 (83.0%)
 ≥20-49.9 mm126 (24.2%)395 (75.8%)
 ≥≥50 mm29 (38.7%)46 (61.3%)
 Missing8 (25.8%)23 (74.2%)
   Median size (range) (mm)
Mini-Mental State Examination (MMSE) score<0.0001
 ≥27-30114 (16.7%)569 (83.3%)
 ≥22-2637 (27.8%)96 (72.2%)
 ≥0-2119 (44.2%)24 (55.8%)
 Missing72 (27.4%)191 (72.6%)
   Median MMSE score (range)
Activities of daily living (ADL) score<0.0001
 Fully independent128 (15.1%)720 (84.9%)
 Dependent in 1 or more category72 (47.4%)80 (52.6%)
 Missing42 (34.4%)80 (65.6%)
Charlson Comorbidity Index (CCI) score<0.0001
 ≥071 (13.3%)462 (86.7%)
 ≥152 (26.1%)147 (73.9%)
 ≥247 (24.0%)149 (76.0%)
 ≥≥358 (38.7%)92 (61.3%)
 Missing14 (31.8%)30 (68.2%)
   Median CCI score (range)<0.0001