HOTAIR regulatory factors
| Factors | Up/down-regulation | Regulatory level | References |
|---|---|---|---|
| Methylation of downstream intergenic CpG island | Downregulation | Transcriptional | 62 |
| Post-synthetic methylation | Downregulation | Post-transcriptional | 4 |
| Functional SNPs across HOTAIR locus | Up/downregulation | Transcriptional/ post-transcriptional | 61 |
| siRNA | Downregulation | Post-transcriptional | 49,51 |
| MiR-141 | Downregulation | Post-transcriptional | 32 |
| Argonaute2 (Ago2) | Downregulation | Post-transcriptional | 32 |
| Osteopontin (OPN) | Upregulation | Transcriptional | 63 |
| IRF1 | Downregulation | Transcriptional | 63 |
| c-Myc | Upregulation | Transcriptional | 29 |
| TGF-β | Upregulation | Transcriptional | 4 |
| Diethylstilbestrol (DES) | Upregulation | Transcriptional | 64 |
| Bisphenol-A (BPA) | Upregulation | Transcriptional | 64 |
| Estrogen receptors (ERs) and ER coregulators | Upregulation | Transcriptional | 64 |
| Type I collagen (Col-1) | Upregulation | Transcriptional | 65 |