Overexpression of HOTAIR in different cancers
| Type | Overexpression of HOTAIR | References |
|---|---|---|
| Breast cancer | Poor prognosis, metastasis, invasion, and short overall survival | 21,35 |
| Esophageal squamous cell carcinoma (ESCC) | Poor prognosis, high TNM stage, invasion, metastasis, and short overall survival | 36,37 |
| Gastric cancer | Tumor staging, venous infiltration, and lymph node metastasis | 38,39 |
| Hepatocellular carcinoma | Invasion of HCC cells, possibility of recurrence | 40–44 |
| Colorectal cancer | Poor prognosis, low survival, and metastasis promotion | 45–47 |
| Gallbladder cancer (GBC) | Promoting carcinogenesis | 29 |
| Bladder cancer (BC) | Poor prognosis and high recurrence rate | 48 |
| Renal carcinoma | Proliferation, invasion, and promotion of tumor growth | 49 |
| Cervical cancer | FIGO stage, aggression, and lymph node metastasis | 30 |
| Epithelial ovarian cancer | Poor prognosis, FIGO stage, lymph node metastasis, overall survival, and metastatic stage of EOC | 50 |
| Endometrial carcinoma | Poor prognosis, lymph node metastasis, EC grade, and overall survival | 51,52 |
| Lung cancer | Invasion and metastasis | 53 |
| Non-small cell lung cancer | Promotion of lymph node metastasis | 54,55 |
| Small-cell lung cancer | Poor prognosis, proliferation and invasion | 56 |
| Nasopharyngeal carcinoma | Poor prognosis, overall survival, proliferation, invasion, and promotion of tumor stage | 31 |
| Melanoma | Invasion and metastasis | 57 |
| Glioma | Poor prognosis, cell cycle progression, and glioma grade | 58 |
| Pancreatic cancer | Proliferation and aggression of tumors | 59 |