Table 2

MiRNAs as regulators of inflammatory signaling in HCC

Name	Targets in HCC	Promote/inhibit	Downstream signaling	Reference
MiR-127-5p	BLVRB	Inhibit	NF-κB	¹⁶⁰
MiR-129-5p	VCP	Inhibit	NF-κB	¹⁶¹
MiR-194	TRIM23, C21ORF91	Inhibit	NF-κB	¹⁶²
MiR-195	TAB 3, IKKα	Inhibit	NF-κB	¹⁶³
MiR-26b	TAK1, TAB 3	Inhibit	NF-κB	¹⁶⁴
MiR-302b	AKT2	Inhibit	NF-κB	¹⁶⁵
MiR-342-3p	IKKγ, TAB 2, TAB 3	Inhibit	NF-κB	¹⁶⁶
MiR-370	Lin28A	Inhibit	NF-κB	¹⁶⁷
MiR-491	SMAD3	Inhibit	NF-κB	¹⁶⁸
MiR-520e	NIK	Inhibit	NF-κB	¹⁶⁹
MiR-622	MAP4K4	Inhibit	NF-κB	¹⁷⁰
MiR-1180	OTUD7B, TNIP2	Promote	NF-κB	¹⁷¹
MiR-301a	GAX	Promote	NF-κB	¹⁷²
MiR-362-5p	CYLD	Promote	NF-κB	¹⁷³
MiR-4262	PDCD4	Promote	NF-κB	¹⁷⁴
MiR-657	TLE	Promote	NF-κB	¹⁷⁵
MiR-451	IKKβ, IL6R	Inhibit	NF-κB, STAT3	^176,177
Let-7	STAT3	Inhibit	STAT3	⁴⁸
MiR-122	c-Met	Inhibit	STAT3	¹⁷⁸
MiR-124	STAT3	Inhibit	STAT3	¹⁷⁹
MiR-125b	IL6R	Inhibit	STAT3	¹⁸⁰
MiR-130b	IRF	Inhibit	STAT3	¹⁸¹
MiR-197	STAT3	Inhibit	STAT3	¹⁸²
MiR-219	SMC4	Inhibit	STAT3	¹⁸³
MiR-26a	IL6	Inhibit	STAT3	¹⁸⁴
MiR-363	S1PR1	Inhibit	STAT3	¹⁸⁵
MiR-637	LIF	Inhibit	STAT3	¹⁸⁶
MiR-155	SOCS1	Promote	STAT3	¹⁸⁷