Table 1

MiRNAs associated with hepatitis virus infection and HCC

Name	Regulated by	Expression	Target(s) in HCC	Reference
Let-7	HBV	Down	RAS, HMGA2, MYC, STAT3	^48–51
MiR-101	HBV	Down	MCL1	^52,53
MiR-132	HBV	Down	PIK3R3	^54,55
MiR-136	HBV	Down	AEG1	⁵⁶
MiR-145	HBV	Down	ROCK1, ADAM17, HDAC2	^57–61
MiR-148	HBV	Down	HPIP	⁶²
MiR-15b	HBV	Down	FUT2, Rab1A	^63,64
MiR-205	HBV	Down	ACSL1	^65,66
MiR-216	HBV	Down	IGF2BP2	⁶⁷
MiR-223	HBV	Down	MYC	⁶⁸
MiR-29c	HBV	Down	TNFAIP3	⁶⁹
MiR-338-3p	HBV	Down	TAZ, CCND1, HIF1A, FOXP4	^70–73
MiR-375	HBV	Down	AEG1	⁵⁶
MiR-429	HBV	Down	NOTCH1, Rab18	^74,75
MiR-103/107	HBV	Up	Maspin, AKAP12	^76,77
MiR-106b	HBV	Up	APC1	^78,79
MiR-125a	HBV	Up	MMP11, VEGF	^80,81
MiR-146a	HBV	Up	CFH, VEGF	^82,83
MiR-181a	HBV	Up	Fas, Met, E2F5	^84–86
MiR-18a	HBV	UP	CTGF	⁸⁷
MiR-19a	HBV	Up	PTEN	⁶⁸
MiR-21	HBV	Up	Maspin	⁷⁶
MiR-29a	HBV	Up	PTEN	⁸⁸
MiR-331-3p	HBV	Up	VHL, ING5	^89,90
MiR-33a	HBV	Up	PBX3, TWIST1	^91,92
MiR-602	HBV	Up	RASSF1A	⁹³
MiR-122	HBV, HCV	Down	CAT1, PEG10	^94,95
MiR-152	HBV, HCV	Down	DNMT1, Wnt1	^96,97
MiR-221	HBV, HCV	Up	ERα	^98,99
MiR-181c	HCV	Down	HOXA1	¹⁰⁰
MiR-203a	HCV	Down	ADAM9	^101,102
MiR-30c	HCV	Down	Snail	^101,103
MiR-155	HCV	Up	APC	¹⁰⁴
MiR-196a	HCV	Up	FOXO1	¹⁰⁵