Key differences in preoperative and postoperative RT
| Item | Preoperative RT | Postoperative RT |
| Dose | Lower dose (50 Gy) | Higher dose (60-66 Gy) |
| Treatment volume | Smaller treatment volume | Larger treatment volume |
| Rate of would complications | More acute wound complications (35%) | Wound complications up to 17% |
| Features | Offers the possibility to perform translational research on the clinicopathological behaviour of individual sarcoma subtypes to RT | Increase late RT toxicities:increased fibrosisincreased edemaincreased joint stiffness |
| Rarely, may provide the option of omission of RT when adequate margins are achieved. Ideally this should be discussed in a multidisciplinary meeting |