The influence of VEGF on different immune and cancer cells
| Cell type | The influence of VEGF on the cell | Reference |
|---|---|---|
| Dendritic cell | Inhibit the differentiation of DC in the hematopoietic process | 30 |
| Influence the function and maturation of DC | 29 | |
| Increase the mDC and pDC in lung | 32 | |
| Enable DC to differentiate into endothelial-like cell | 33 | |
| Enable DC to get an angiogenic property | 34 | |
| Macrophage | Prevent inflammation during bacterial infection | 35 |
| Mediate the infiltration of macrophage in the lung | 36 | |
| T lymphocyte | Cause thymic atrophy | 37 |
| Costimulate IFN-γ production, increase chemotaxis | 38 | |
| Induce epithelial activation, neutrophil chemotaxis in OAD | 39 | |
| Treg | Promote the induction and maintenance of Treg in the tumor site | 40 |
| Chemotaxis for Treg | 5 | |
| Tumor cell | Increase the migration, cell mobility and invasiveness of tumor cells | 41–43 |
| Promote cancer stemness | 44 |
VEGF, vascular endothelial growth factor; DC, dendritic cell; mDC, myeloid DC; pDC, plasmacytoid DC; OAD, obliterative airway disease.