Multivariate analysis of predictive factors associated with overall survival (OS) and disease-free survival (DFS)
| Variables | OS | DFS | ||||
| β | HR (95%CI) | P | β | HR (95%CI) | P | |
| Tumor size (cm) | 0.015 | 0.005 | ||||
| 5–10/<5 | 0.789 | 2.200 (1.185–4.085) | 0.013 | 0.576 | 1.779 (1.019–3.104) | 0.043 |
| ≥ 10/<5 | 0.950 | 2.586 (1.346–4.968) | 0.004 | 1.002 | 2.724 (1.490–4.981) | 0.001 |
| MVI | ||||||
| Yes/no | 0.509 | 1.664 (0.962–2.879) | 0.069 | 0.508 | 1.129 (0.729–1.750) | 0.587 |
| TBIL (μmol/L) | ||||||
| > 17.1/≤ 17.1 | 0.238 | 1.269 (0.808–1.991) | 0.301 | 0.191 | 1.211 (0.789–1.859) | 0.382 |
| AFP (ng/mL) | 0.003 | 0.008 | ||||
| 20–400/≤ 20 | 0.576 | 1.779 (0.782–4.048) | 0.170 | 0.491 | 1.633 (0.758–3.518) | 0.210 |
| > 400/≤ 20 | 0.967 | 2.629 (1.495–4.624) | 0.001 | 0.794 | 2.212 (1.337–3.659) | 0.002 |
| ALP (U/L) | ||||||
| > 100.5/≤ 100.5 | 0.560 | 1.751 (1.070–2.865) | 0.026 | 0.559 | 1.749 (1.074–2.848) | 0.025 |
| BT in hospital | ||||||
| Yes/no | 0.157 | 1.170 (0.748–1.831) | 0.491 | 0.121 | 1.129 (0.729–1.750) | 0.587 |
| AST (U/L) | ||||||
| > 40/≤ 40 | 0.097 | 0.907 (0.579–1.422) | 0.672 | |||
β, the coefficients in the COX regression; HR, hazard ratio; CI, confidence interval; MVI, macroscopic vascular invasion; TBIL, total bilirubin; AFP, α-fetoprotein; ALP, alkaline phosphatase; BT, blood transfusion; AST, aspartate aminotransferase.