PFS and OS of each variable from the subgroups were divided on the basis of the cutoff values

	PFS		OS
	Median	P	Median	P
Post-treatment ECOG				0.0031
0-1 point			9.93
2-3 point			7.26
Post-treatment granulocytes/lymphocytes ratio		0.0008		< 0.0001
≤ 3.1	5.97		11.16
> 3.1	4.45		8.18
Pre-randomization maximal target lesion length (mm)				0.0002
≤ 72			10.38
> 72			7.98
Hypertension		< 0.0001
Yes	5.65
No	3.42
Hand-foot syndrome		< 0.0001
Yes	6.51
No	3.80
Hyperglycemia		0.0003
Yes	5.60
No	3.93
Hypertriglyceridemia		< 0.0001		< 0.0001
Yes	5.67		10.23
No	3.41		7.29
Elevated thyroid stimulating hormone		< 0.0001
Yes	5.66
No	3.61
Elevated alkaline phosphatase		0.0286
Yes	4.23
No	5.32