Univariate and multivariate survival analyses of the prognostic factors for overall and disease-free survival in EOC patients

Variable	n	Progression-free survival					Overall survival
		Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
		Media of PFS	P^a	HR	95% CI For HR	P^b	Media of OS	P^a	HR	95% CI For HR	P^b
Age (years)			0.621	NA	NA	NA		0.676	NA	NA	NA
≤51	136	30					42
>51	95	31					44
Menopause			0.373	NA	NA	NA		0.488	NA	NA	NA
Yes	154	30					43
No	77	32					44
Pathologic type			0.978	NA	NA	NA		0.849	NA	NA	NA
Serous	116	30					41
Mucous and others*	115	31					44
Histologic grade			0.025	1.083	0.802– 1.462	0.604		0.114	NA	NA	NA
G1–2	141	42					44
G3	90	34					40
FIGO stage			<0.001	2.265	1.632– 3.144	<0.001		<0.001	1.994	1.423– 2.792	<0.001
I–II	81	44					58
III –IV	150	24					39
LN metastasis			0.019	1.366	0.958– 1.947	0.085		0.035	1.274	0.887– 1.829	0.190
No	186	31					43
Yes	45	24					41
Residual tumor (cm)			0.277	NA	NA	NA		0.806	NA	NA	NA
<1	187	31					43
≥ 1	44	30					41
Ascites volume (mL)			0.237					0.403	NA	NA	NA
≤1000	157	40		NA	NA	NA	55
>1000	74	36					58
Serum CA125 (U/mL)			0.753	NA	NA	NA		0.991	NA	NA	NA
≤675	140	36					55
>675	91	39					55
PVT1 expression			0.016	1.111	0.819– 1.506	0.498		0.020	1.153	0.842– 1.579	0.375
Low	101	34					51
High	130	28					40
MiR-214 expression			0.021	1.246	0.925– 1.680	0.148		0.034	1.193	0.880– 1.616	0.256
Low	130	28					41
High	101	31					44

P^a: P value, log rank test; HR: hazard ratio; CI: confidence interval; P^b: P value, Cox regression; CR: complete response; PR: partial response; SD: table disease; PD: progressive disease; NA: not applicable. *Others: others include the endometrioid, clear cell, and undifferentiated ovarian cancers.