Table 2

Surgery versus RFA

Study and year	Type of study	Treatment	No. of patients	Tumor size (range) (cm)	Overall survival (%)			P	Disease free survival (%)		P
Study and year	Type of study	Treatment	No. of patients	Tumor size (range) (cm)	2 years	3 years	5 years		3 years	5 years
White et al., 2007⁶¹	R	Surg	30	2.5 (1.0–5.0)	100	82	65	N/A	51	36	N/A
		RFA	22	2.0 (1.0-5.0)	100	28	0		0	0
Gleisner et al., 2008⁶²	R	Surg	192	3.5 (2.0-5.0)		72	54	0.01	41	41	0.01
		RFA	11	2.5 (1.9-4.0)		51	28		9	0
Berber et al., 2008⁶³	R	Surg	90	3.8		70	40	0.35	45	38	N/A
		RFA	68	3.7		35	30		29	0
Lee et al., 2008⁶⁴	R	Surg	116	3.3 (0.5-18.0)		51	66	0.23	88	85	N/A
		RFA	37	2.25 (0.8-5.0)		32	49		53	43
Hur et al., 2009⁶⁵	R	Surg	42	2.6 (0.6-8.0)		70	50	0.026			0.03
		RFA	25	2.5 (2.8-3.6)		60	26
Reuter et al., 2009⁶⁶	R	Surg	192	5.3		55	23	NS	42	24	N/A
		RFA	66	3.2		42	21		24	8
McKay et al., 2009⁶⁷	R	Surg	58	4.1 (1.5-14.5)		60	43	0.021
		RFA	43	3.0 (1.0-7.5)		39	23
Otto et al., 2010⁶⁸	P	Surg	28	5.0 (1.0-15.0)		60	51	0.721	40	30	N/A
		RFA	82	2.0 (1.0-5.0)		67	48		18	18
Schiffman et al., 2010⁶⁹	R	Surg	92	5.6	92	81	65	0.005
		RFA	81	3.9	81	64	42
Lee et al., 2012⁷⁰	R	Surg	25	4.0 (0.7-9.7)		68	44	0.001	40	12	0.004
		RFA	28	2.0 (1.0-4.8)		36	18		11	0
Kim et al., 2011⁷¹	R	Surg	278	2.6		59	45	0.007	32	28	0.004
		RFA	177	2.1		50	36		26	20

P, prospective; R, retrospective; RFA, radiofrequency ablation.