Clinical and therapeutic aspects of cases reported in the literature
| Reference | Age, yrs | Gender | Clinical presentation | Biology (UI/L) | Radiology | Pathology | Other paraneoplastic symptoms | Treatment | Evolution and follow up |
|---|---|---|---|---|---|---|---|---|---|
| Ko et al.3 | 25 | F | Incidental | ASAT: 1158 ALAT: 943 PAL: 106 ANA+ SM– LKM1– | Not mentioned | Active chronic hepatitis | Myasthenia gravis Polymyosite | Prednisolone Aziathiopirine | ASAT/ALAT normal after 2 months |
| Han et al.4 | 30 | M | Fatigue Weakness | ASAT: 400 ALAT: 777 ANA+ ASM–/AM– | No bile duct dilatation | Chronic active hepatitis | Myasthenia | Prednisolone | ASAT/ALAT normal after 1 month |
| Askawa et al.5 | 77 | F | Jaundice Ascitis Fatigue | ASAT: 392 ALAT: 280 ANA–/ASM–LKM1– | No bile duct dilatation | Necropsied specimen: auto immune hepatitis | Diabetis Mellitis Myasthenia gravis Hashimoto’s thyroiditis | Vitamin K Plasmapherese | Died from acute hepatitis |
| Kim et al.6 | 35 | F | Pruritis Jaundice Fatigue | ASAT: 125 ALAT: 22 ANA+/ASM– LKM1–/AM– | No parenchymal or bile duct abnormalities | Chronic non suppurative destructive cholongitis | No | Ursodeoxy chloric acid | Normal biology for 36 months |
| Aigner et al.7 | 56 | F | Loss of appetitis Jaundice | ASAT: 1912 ALAT: 1332 ANA/ASM/ | Not mentioned | AIH | Myasthenia gravis after AIH revealing thymoma | Predisone | Normal biology for 48 months |
| Yapali et al.8 | 31 | M | Jaundice Fatigue Nausea | ASAT: 370 ALAT: 249 PAL: 152 GT: 208 ANA–/ASM– AM– | No bile duct dilatation | Acute liver hepatitis | Myasthenia gravis Hashimoto’s Thyroiditis Connective tissue disorder | Prednisolone | Normal biology after 6 months |
M, male; F, female; ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; PAL, alkaline phosphatase; GT, gamma glutamyl transferase; AAN, anti-nuclear antibody; ASM, anti smooth muscle antibody; AM, anti mitochondrial antibody; LKM1, anti liver/kidney microsome antibody.