Mechanism of miRNA-regulated T cells

Stage	MiRNAs	Cell expression and mechanism	Reference
Development	MiR-125b	MiR-125b is involved in hematopoietic stem cell survival in lymphoid balance	Ooi et al.²¹
	MiR-181a	MiR-181a enhances DP cell antigen sensitivity, and inhibits Bcl-2, CD69 expression, and TCR effects the positive clone selection of T cells	Wu et al.⁸
			Liu et al.²²
			Li et al.²⁵
	MiR-150	During T cell maturation process, upregulation miR-150 inhibits the expression of the target gene NOTCH3	Ghisi et al.²⁷
Activation Proliferation Apoptosis	MiR-214	After stimulation, highly expressed miR-214 inhibited target gene PTEN expression in the proliferation of T cells	Jindra et al.¹⁸
	MiR-130/301	During CD8⁺T cell activation, miR-130 and MiR-301 are upregulated, inhibit of CD69 expression	Zhang et al.²⁸
	MiR-155 MiR-221	High expressions of miR-155 and miR-221 inhibited the expression of PIK3R1 in CD4⁺T cells	Grigoryev et al.²⁹
	MiR-182	MiR-182 binds to 3′-UTR of mRNA of Foxo1 in T helper cells	Stittrich et al.³⁰
	MiR-21	MiR-21 regulates the survival of activated memory T cell and induces CCR-7 expression in activated naive T cells	Smigielska-Czepiel et al.³¹
	MiR-17∼92	In Th1 cells, miR-19 and miR17 target PTEN and CREB1, respectively, are involved in Th1 cell immune response. MiR-17∼92 gene cluster exhibits reduced expression and inhibits Bim and PTEN expressions, which affect apoptosis	Jiang et al.³³
	MiR-17∼92		Xiao et al.³⁶
	MiR-150	MiR-150 and miR-139 regulate perforin, eomesodermin, and IL-2Rα expressions in differentiation CTL cell, involved in inflammation and antigen stimulation	Trifari et al.³⁷
	MiR-139		Trifari et al.³⁷
	MiR-15a/16-1	MiR-15a/16-1 is downregulated, the upregulated target gene Bcl-2 affects the progression of apoptosis in CD4⁺T cells	Lorenzi et al.³⁸
	MiR-17∼92	MiR-17∼92 gene cluster inhibits Bim expression, which facilitates glucocorticoid-induced apoptosis in CD4⁺T cells	Molitoris et al.⁴⁰
	MiR-122	In apoptosis CTCL cells, miR-122 is upregulated, which activates Akt-related pathway; indicated that miR-122 amplifies the Akt/p53 anti-apoptosis pathway	Manfè et al.⁴¹
The development of functional peripheral T cell subset	MiR-150	In IL-15/IL-2-induced CD8 T cells, the target gene of miR-150 is KChiP1, which affects cell phenotype and self-renewal capacity via a negative feedback pathway	Almanza et al.⁴²
	MiR-142-5p	MiR-142-5p associated with CD4+CD25+ T cell proliferation by binding to the 3′-UTR of mRNA of GARP	Zhou et al.⁴³
	MiR-29	MiR-29 regulates T-box transcription factors and IFN-γ production in Th cells	Ma et al.45 Steiner et al.⁴⁶
	MiR-125p	MiR-125p terminates the differentiation from naïve T cells to effector cells	Rossi et al.⁴⁸
	MiR-24 MiR-210 MiR-145	MiR-24, miR-210, miR-95, and miR-145 are upregulated, miR-24 and miR-210 miR-95 regulate FOXP3 expression miR-145 negatively regulates the CTLA-4 expression in Treg cells	Fayyad-Kazan et al.⁴⁹
	MiR-10a	MiR-10a restricted Treg cell differentiation into Th17 cells	Takahashi et al.⁵⁰
	MiR-155	MiR-155 is upregulated, FOXOa3, the target gene of miR-155, negatively affect the Akt signaling pathway in stimulated Treg cells	Yamamoto et al.⁵¹
	MiR-146	MiR-146 inhibits STAT1 expression by controlling Th1 response via Treg cell-mediated regulation	Lu et al.⁵²
Cancer immunity	MiR-222 MiR-339	Dicer-regulated miR-222 and miR-339 promote resistance of cancer cells to cytotoxic T-lymphocytes by downregulating of ICAM-1	Ueda et al.⁵⁴
	MiR-513	Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by downregulating miR-513	Gong et al.⁵⁵
	MiR-29	MiR-29 modulates the expression of the immunoinhibitory molecule B7-H3	Xu et al.⁵⁶
	MiR-122	MiR-122 binds the IL-1α 3’-untranslated region	Gao et al.⁵⁷