Geometric means (95% confidence intervals) of tumor tissue mRNA levels for the TGF-β1, TβR-Ⅰ, and TβR-Ⅱ genes in patients with breast cancer and benign breast disease.
| Item | TGF-β type II receptor | TGF-β type I receptor | TGF-β I | TGF-β I/TβR-II | TGF-β I/TβR-I | ||||
|---|---|---|---|---|---|---|---|---|---|
| Benign breast diseases | |||||||||
| Nonproliferative lesions (n=124) | 122.67 (107.13-140.47) | 6.80 (6.06-7.63) | 82.49 (67.74-100.46) | 0.69 ((0.55-0.86) | 11.13 (8.68-14.26) | ||||
| Proliferative lesions (n=94) | 102.21 (88.14-118.52) | 7.56 (6.71-8.50) | 73.04 (60.24-88.57) | 0.70 (0.57-0.85) | 9.18 (7.27-11.60) | ||||
| P-value a | 0.077 | 0.216 | 0.398 | 0.936 | 0.281 | ||||
| Breast cancer (by stage) | |||||||||
| 0 and I(n=124) | 54.55 (46.83-63.53) | 6.39 (5.81-7.03) | 64.67 (58.06-72.03) | 1.17 (1.00-1.36) | 9.80 (8.42-11.41) | ||||
| II a (n=210) | 51.48 (45.46-58.30) | 6.29 (5.76-6.87) | 62.71 (57.63-68.23) | 1.21 (1.08-1.36) | 9.80 (8.63-11.12) | ||||
| II b (n=132) | 47.50 (40.52-55.69) | 6.97 (6.17-7.88) | 63.66 (56.49-71.74) | 1.32 (1.12-1.55) | 9.12 (7.84-10.61) | ||||
| III and IV (n=51) | 70.61 (54.92-90.78) | 6.21 (5.33-7.23) | 70.24 (59.57-82.81) | 0.99 (0.79-1.26) | 11.31 (9.32-13.73) | ||||
| P-value for trend test b | 0.547 | 0.594 | 0.587 | 0.858 | 0.757 | ||||
| Benign breast diseases (n=218) | 113.18 (102.35-125.15) | 7.13 (6.56-7.74) | 78.26 (68.08-89.96) | 0.69 (0.59-0.81) | 10.22 (8.60-12.15) | ||||
| Breast cancer (n=517) | 52.73 (48.73-57.05) | 6.48 (6.13-6.84) | 64.12 (60.69-67.75) | 1.20 (1.11-1.30) | 9.76 (9.04-10.53) | ||||
| P-value c | <0.001 | <0.001 | 0.002 | <0.001 | 0.577 | ||||