Association of tumor tissue mRNA levels of the TβR-II and TGF-β1 genes with breast cancer patient survival.
| Overall survival | Disease-free survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of patients | No. of event | 5-year survival rate (%) | Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | No. of event | 5-year survival rate (%) | Unadjusted HR (95% CI) | Adjusted HR a (95% CI) | |
| TGF-β type II receptor | |||||||||
| T1 | 168 | 36 | 79.9 | 1.0 | 1.0 | 40 | 76.3 | 1.0 | 1.0 |
| T2 | 171 | 17 | 90.3 | 0.43 (0.24-0.77) | 0.47 (0.27-0.85) | 26 | 84.4 | 0.59 (0.36-0.97) | 0.65 (0.39-1.06) |
| T3 | 168 | 32 | 81.0 | 0.86 (0.54-1.39) | 0.94 (0.58-1.51) | 37 | 78.3 | 0.89 (0.57-1.40) | 0.98 (0.63-1.53) |
| TGF-β1 | |||||||||
| T1 | 175 | 32 | 82.4 | 1.0 | 1.0 | 38 | 78.0 | 1.0 | 1.0 |
| T2 | 173 | 25 | 87.1 | 0.76 (0.45-1.28) | 0.76 (0.45-1.28) | 33 | 81.6 | 0.86 (0.54-1.38) | 0.86 (0.54-1.37) |
| T3 | 174 | 27 | 83.8 | 0.83 (0.50-1.38) | 0.83 (0.49-1.38) | 34 | 80.1 | 0.88 (0.55-1.39) | 0.88 (0.55-1.39) |
| TGF-β1/TβR-II ratio | |||||||||
| T1 | 169 30 | 82.4 | 1.0 | 1.0 | 38 | 77.9 | 1.0 | 1.0 | |
| T2 | 168 | 20 | 89.4 | 0.64 (0.37-1.14) | 0.59 (0.33-1.04) | 23 | 86.0 | 0.57 (0.34-0.96) | 0.52 (0.31-0.88) |
| T3 | 168 | 34 | 80.0 | 1.19 (0.73-1.95) | 1.10 (0.67-1.80) | 41 | 75.6 | 1.13 (0.73-1.75) | 1.05 (0.67-1.63) |
↵a Adjusted for age and stage.