Table 1.

Effect of US on cellular drug sensitivity (Embedded Image).

IC50* (mg/L)RI**
CellsDNRADMDNRADM
HepG20.002 ± 0.00060.003 ± 0.00081.01.0
HepG2/ADM0.202 ± 0.00760.315 ± 0.0254101105
HepG2/ADM + US0.072 ± 0.00020.097 ± 0.000936.031.3
HepG2/ADM + VER0.084 ± 0.00070.094 ± 0.00654231.3
HepG2/ADM + VER + US0.012 ± 0.00110.027 ± 0.001469

  • ↵* mean standard deviation of at least three experiments;

  • ↵** mean of three experiments; RI, resistance index. All values were calculated as described in MATERIALS AND METHODS. The concentration of verapamil (VER) was15.7 μM and the treatment time was 4 h.