Analysis of the correlation factors with lymph node metastases.
| Lymph node negative | Lymph node positive | P value | |
|---|---|---|---|
| CXCR4 cytoplasmic positivity* | 14.3% (1/7) | 26.3 (21/80) | 0.013 |
| HER2 positive** | 14.3% (1/7) | 28.8% (23/80) | 0.011 |
| CXCR4 cytoplasm/HER2 positivity | 28.6% (2/7) | 51.3% (41/80) | 0.003 |
↵* High CXCR4 expression was confirmed when strong positive staining was present in more than 30% of the cells, or moderate staining present in more than 50% of tumor cells;
↵** HER2 positivity was confirmed as complete or strong positive cytoplasmic staining when present in more than 10% of the tumor cells.