The comparative analysis of EGFR, K-RAS gene mutations and protein expression with clinicopathological parameters (χ2 test).
| Characteristics | Cases | EGFR mutation (+) | EGFR protein (+) | K-RAS mutation (+) | K-RAS protein (+) | ||||
|---|---|---|---|---|---|---|---|---|---|
| % | P | % | P | % | P | % | P | ||
| Age (years) | |||||||||
| < 65 | 131 | 41.2 | 16.0 | 4.6 | 53.4 | ||||
| ≥ 65 | 69 | 17.4 | 0.001 | 15.9 | 0.987 | 7.2 | 0.646 | 50.7 | 0.715 |
| Sex | |||||||||
| Male | 117 | 19.7 | 12.8 | 6.8 | 54.7 | ||||
| Female | 83 | 51.8 | 0.000 | 20.5 | 0.145 | 3.6 | 0.503 | 49.4 | 0.459 |
| Smoking history | |||||||||
| Yes | 120 | 52.5 | 10.0 | 7.5 | 50.0 | ||||
| No | 80 | 20.0 | 0.000 | 25.0 | 0.005 | 2.5 | 0.229 | 56.3 | 0.386 |
| Histology types | |||||||||
| Adenocarcinoma | 111 | 50.5 | 18.0 | 6.3 | 49.5 | ||||
| Squamous carcinoma | 68 | 2.9 | 10.3 | 2.9 | 60.3 | ||||
| Adenosquamous carcinoma | 8 | 87.5 | 37.5 | 0 | 37.5 | ||||
| Large cell carcinoma | 9 | 11.1 | 0.0 | 0 | 55.6 | ||||
| Sarcomatoid carcinoma | 4 | 0 | 0.000 | 50.0 | 0.041 | 50.0 | 0.053 | 25.0 | 0.396 |
| Lymph node metastasis | |||||||||
| Yes | 85 | 32.9 | 20.0 | 3.5 | 49.4 | ||||
| No | 115 | 33.0 | 0.988 | 13.0 | 0.185 | 7.0 | 0.461 | 54.8 | 0.452 |
P < 0.05 was considered a statistically significant difference.