Univariate and multivariate analysis of prognostic factors in pancreatic ductal adenocarcinoma
| Clinicopathological parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| MEG3 expression | ||||||
| High | 1 | |||||
| Low | 2.805 | 1.108–7.105 | 0.011 | 2.932 | 1.149–7.484 | 0.018* |
| miR-374a-5p expression | ||||||
| High | 3.292 | |||||
| Low | 1 | 1.206–8.990 | 0.02 | 6.393 | 1.115–36.649 | 0.037* |
| Age (years) | ||||||
| ≤ 60 | 1 | |||||
| > 60 | 1.129 | 0.483–2.639 | 0.779 | |||
| Gender | ||||||
| Male | 1 | |||||
| Female | 0.819 | 0.370–2.193 | 0.819 | |||
| Tumor location | ||||||
| Head, neck | 1 | |||||
| Body, tail | 1.227 | 0.698–2.159 | 0.477 | |||
| Tumor size (cm) | ||||||
| ≤ 3 | 0.75 | |||||
| > 3 | 1 | 0.336–1.675 | 0.481 | |||
| Invasion depth | ||||||
| T1 + T2 | 1 | |||||
| T3 + T4 | 1.429 | 0.566–3.604 | 0.447 | |||
| Lymph nodes metastasis | ||||||
| N0 (negative) | 1 | |||||
| N1 (positive) | 0.933 | 0.408–2.133 | 0.87 | |||
| Clinical stage | ||||||
| Early stages (≤ II) | 1 | 1 | ||||
| Advanced stages (> II) | 2.55 | 1.112–5.851 | 0.018 | 2.703 | 1.164–6.276 | 0.021* |
| Nervous system invasion | ||||||
| Negative | 1 | |||||
| Positive | 1.048 | 0.447–2.453 | 0.915 | |||
HR, hazard ratio; 95% CI. 95% confidence interval, *P < 0.05.