Methods proposed for reprogramming the tumor microenvironment
| Cancer type/model | Methods | References |
|---|---|---|
| Breast cancer | Treatment of MSCs with eicosapentanoic acid | 106 |
| Encapsulation of MSCs with sodium alginate | 107 | |
| Prostate cancer | Extended passaging of CAFs | 108 |
| Elimination of tumor immunosuppressive cells with chimeric protein IL2-R336A | 109 | |
| Lung cancer | MSCs loading with the photosensitizer MnO2@Ce6 | 110 |
| MSCs loading with nanoparticles | 111 | |
| Hepatocellular carcinoma | MSCs carrying an adenovirus | 112 |
| Treatment of MSCs with melatonin | 113 | |
| Colon cancer | MSCs arming with a double fusion gene containing the herpes simplex virus truncated thymidine kinase and firefly luciferase | 114 |
| Liver cancer | Irradiation of endothelial cells | 115 |
| Neuroblastoma | Autologous MSCs carrying an oncolytic adenovirus | 75 |
| Myelodysplastic syndrome | Treatment of MSCs with 5-azacytidine | 116 |