Table 1

Univariate analyses and multivariate analysis of prognostic markers for OS

Variable	Univariate analysis		Multivariate analysis
Variable	HR (95% CI)	P	HR (95% CI)	P
Age
< 60 vs. ≥ 60	1.816 (1.135–2.906)	0.013	2.067 (1.286–3.321)	0.003
Gender
Male vs. female	0.598 (0.372–0.962)	0.034
Smoking history
Yes vs. No	0.707 (0.441–1.132)	0.148
TNM stage		0.002		< 0.001
I	1
II	3.336 (1.154–9.641)	0.026		0.017
III	5.394 (1.929–15.082)	0.001	0.410 (0.254–0.662)	< 0.001
CD8⁺TILs
Low vs. high	0.600 (0.370–0.971)	0.037
TCF1⁺CD8⁺TILs
Low vs. high	0.550 (0.341–0.888)	0.014
COX2
Low vs. high	1.606 (1.002–2.572)	0.049	1.880 (1.168–3.028)	0.009