PT  - JOURNAL ARTICLE
AU  - Zhou, Dong-Mei
AU  - Chen, Gang
AU  - Zheng, Xiong-Wei
AU  - Zhu, Wei-Feng
AU  - Chen, Bao-Zhen
TI  - Clinicopathologic features of 112 cases with mantle cell lymphoma
AID  - 10.7497/j.issn.2095-3941.2015.0007
DP  - 2015 Mar 01
TA  - Cancer Biology and Medicine
PG  - 46--52
VI  - 12
IP  - 1
4099  - http://www.cancerbiomed.org/content/12/1/46.short
4100  - http://www.cancerbiomed.org/content/12/1/46.full
SO  - Cancer Biol Med2015 Mar 01; 12
AB  - Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.