<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hingorani, Mohan</style></author><author><style face="normal" font="default" size="100%">Dixit, Sanjay</style></author><author><style face="normal" font="default" size="100%">Pugazhenthi, Pattu</style></author><author><style face="normal" font="default" size="100%">Hawkyard, Simon</style></author><author><style face="normal" font="default" size="100%">Robertson, Andrew</style></author><author><style face="normal" font="default" size="100%">Khafagy, Richard</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Can palliative radiotherapy influence prostate-specific antigen response in patients with castrate-resistant prostate cancer treated with systemic therapy (chemotherapy or abiraterone)?—a report of three cases</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Biology and Medicine</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">60-63</style></pages><doi><style  face="normal" font="default" size="100%">10.7497/j.issn.2095-3941.2014.0025</style></doi><volume><style face="normal" font="default" size="100%">12</style></volume><issue><style face="normal" font="default" size="100%">1</style></issue><abstract><style  face="normal" font="default" size="100%">Palliative radiotherapy (pRT) is primarily employed for palliation of bone pain in patients with castrate-resistant prostate cancer (CRPC). However, evidence that pRT influences prostate-specific antigen response in patients with CRPC on systemic therapy is lacking. We describe three cases of CRPC progressing after treatment with docetaxel (n=2) and abiraterone (n=1), who responded unusually after pRT for bone pain with the development of a significant biochemical response and restoration of response to systemic therapy. The possibility of pRT influencing metastatic disease in CRPC has not been previously reported, and raises the possibility of radiation-induced modulation of anti-tumor immune response mechanisms that may play a role in the restoration of response to systemic treatment.</style></abstract></record></records></xml>