PT  - JOURNAL ARTICLE
AU  - Wei Chen
AU  - Guo-Hua Hu
TI  - Biomarkers for enhancing the radiosensitivity of nasopharyngeal carcinoma
AID  - 10.7497/j.issn.2095-3941.2014.0015
DP  - 2015 Mar 01
TA  - Cancer Biology and Medicine
PG  - 23--32
VI  - 12
IP  - 1
4099  - http://www.cancerbiomed.org/content/12/1/23.short
4100  - http://www.cancerbiomed.org/content/12/1/23.full
SO  - Cancer Biol Med2015 Mar 01; 12
AB  - Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy. The incidence of NPC is higher in Southern China and Southeast Asia compared with Western countries. Given its high radiosensitivity, the standard treatment for NPC is radiotherapy. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after treatment by radiation. Thus, special emphasis has been given to the discovery of effective radiosensitizers. This review aims to discuss the biomarkers, classified according to the main mechanisms of radiosensitization, which can enhance the sensitivity of NPC cells to ionizing radiation.