PT  - JOURNAL ARTICLE
AU  - Xiao-Yu Zhang
AU  - Wei-Yue Lu
TI  - Recent advances in lymphatic targeted drug delivery system for tumor metastasis
AID  - 10.7497/j.issn.2095-3941.2014.04.003
DP  - 2014 Dec 01
TA  - Cancer Biology and Medicine
PG  - 247--254
VI  - 11
IP  - 4
4099  - http://www.cancerbiomed.org/content/11/4/247.short
4100  - http://www.cancerbiomed.org/content/11/4/247.full
SO  - Cancer Biol Med2014 Dec 01; 11
AB  - The lymphatic system has an important defensive role in the human body. The metastasis of most tumors initially spreads through the surrounding lymphatic tissue and eventually forms lymphatic metastatic tumors; the tumor cells may even transfer to other organs to form other types of tumors. Clinically, lymphatic metastatic tumors develop rapidly. Given the limitations of surgical resection and the low effectiveness of radiotherapy and chemotherapy, the treatment of lymphatic metastatic tumors remains a great challenge. Lymph node metastasis may lead to the further spread of tumors and may be predictive of the endpoint event. Under these circumstances, novel and effective lymphatic targeted drug delivery systems have been explored to improve the specificity of anticancer drugs to tumor cells in lymph nodes. In this review, we summarize the principles of lymphatic targeted drug delivery and discuss recent advances in the development of lymphatic targeted carriers.