RT Journal Article
SR Electronic
T1 Mechanism of T cell regulation by microRNAs
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 131
OP 137
DO 10.7497/j.issn.2095-3941.2013.03.002
VO 10
IS 3
A1 Juan Liu
A1 Chang-Ping Wu
A1 Bin-Feng Lu
A1 Jing-Ting Jiang
YR 2013
UL http://www.cancerbiomed.org/content/10/3/131.abstract
AB MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that can modulate target gene expression at post-transcriptional level and participate in cell proliferation, differentiation, and apoptosis. T cells have important functions in acquired immune response; miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell development, proliferation, differentiation, and function. For instance, miR-181 family members function in progression by targeting Bcl2 and CD69, among others. MiR-17 to miR-92 clusters function by binding to CREB1, PTEN, and Bim. Considering that the suppression of T cell-mediated immune responses against tumor cells is involved in cancer progression, we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.