PT  - JOURNAL ARTICLE
AU  - Juan Liu
AU  - Chang-Ping Wu
AU  - Bin-Feng Lu
AU  - Jing-Ting Jiang
TI  - Mechanism of T cell regulation by microRNAs
AID  - 10.7497/j.issn.2095-3941.2013.03.002
DP  - 2013 Sep 01
TA  - Cancer Biology and Medicine
PG  - 131--137
VI  - 10
IP  - 3
4099  - http://www.cancerbiomed.org/content/10/3/131.short
4100  - http://www.cancerbiomed.org/content/10/3/131.full
SO  - Cancer Biol Med2013 Sep 01; 10
AB  - MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that can modulate target gene expression at post-transcriptional level and participate in cell proliferation, differentiation, and apoptosis. T cells have important functions in acquired immune response; miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell development, proliferation, differentiation, and function. For instance, miR-181 family members function in progression by targeting Bcl2 and CD69, among others. MiR-17 to miR-92 clusters function by binding to CREB1, PTEN, and Bim. Considering that the suppression of T cell-mediated immune responses against tumor cells is involved in cancer progression, we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.