RT Journal Article
SR Electronic
T1 Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 880
OP 897
DO 10.20892/j.issn.2095-3941.2024.0231
VO 21
IS 10
A1 Shen, Jianlin
A1 Lai, Yue
A1 Wu, Yanjiao
A1 Lin, Xuan
A1 Zhang, Cheng
A1 Liu, Huan
YR 2024
UL http://www.cancerbiomed.org/content/21/10/880.abstract
AB Ubiquitination, a multifaceted post-translational modification, regulates protein function, degradation, and gene expression. The pivotal role of ubiquitination in the pathogenesis and progression of cancer, including colorectal, breast, and liver cancer, is well-established. Osteosarcoma, an aggressive bone tumor predominantly affecting adolescents, also exhibits dysregulation of the ubiquitination system, encompassing both ubiquitination and deubiquitination processes. This dysregulation is now recognized as a key driver of osteosarcoma development, progression, and chemoresistance. This review highlights recent progress in elucidating how ubiquitination modulates tumor behavior across signaling pathways. We then focus on the mechanisms by which ubiquitination influences osteosarcoma cell function. Finally, we discuss the potential for targeting the ubiquitin-proteasome system in osteosarcoma therapy. By unraveling the impact of ubiquitination on osteosarcoma cell physiology, we aim to facilitate the development of novel strategies for prognosis, staging, treatment, and overcoming chemoresistance.