RT Journal Article
SR Electronic
T1 The role of reactive oxygen species in gastric cancer
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 20240182
DO 10.20892/j.issn.2095-3941.2024.0182
A1 Wang, Yuqi
A1 Xu, Jingli
A1 Fu, Zhenjie
A1 Zhang, Ruolan
A1 Zhu, Weiwei
A1 Zhao, Qianyu
A1 Wang, Ping
A1 Hu, Can
A1 Cheng, Xiangdong
YR 2024
UL http://www.cancerbiomed.org/content/early/2024/08/08/j.issn.2095-3941.2024.0182.abstract
AB Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.