PT - JOURNAL ARTICLE AU - Wang, Yuqi AU - Xu, Jingli AU - Fu, Zhenjie AU - Zhang, Ruolan AU - Zhu, Weiwei AU - Zhao, Qianyu AU - Wang, Ping AU - Hu, Can AU - Cheng, Xiangdong TI - The role of reactive oxygen species in gastric cancer AID - 10.20892/j.issn.2095-3941.2024.0182 DP - 2024 Jul 09 TA - Cancer Biology & Medicine PG - 20240182 4099 - http://www.cancerbiomed.org/content/early/2024/08/08/j.issn.2095-3941.2024.0182.short 4100 - http://www.cancerbiomed.org/content/early/2024/08/08/j.issn.2095-3941.2024.0182.full AB - Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.