RT Journal Article
SR Electronic
T1 Primary peritoneal carcinoma metastasizing to breast: a single case report and literature review from clinic to biology
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 389
OP 395
DO 10.20892/j.issn.2095-3941.2016.0058
VO 13
IS 3
A1 Ji-Yuan Sun
A1 Wondwossen Gebre
A1 Yi-Min Dong
A1 Xiao Shaun
A1 Rachel Robbins
A1 Alida Podrumar
YR 2016
UL http://www.cancerbiomed.org/content/13/3/389.abstract
AB Primary peritoneal carcinoma (PPC) is a type of rare malignant epithelial tumor. Metastasis from PPC to breast has been rarely reported. PPC originates de novo from the peritoneal tissues rather than invasion or metastasis from adjacent or remote organs. PPCs have been implicated in many cases of carcinomas of unknown primary origin. It is similar to ovarian cancer (OvCa), because it shares the same common embryonic origin, the coelomic epithelium (mesodermal origin). The mechanism of oncogenesis remains elusive. In this article, we report a rare case of PPC in a patient 10 years after total abdominal hysterectomy and bilateral salpingooophorectomy for uterine leiomyoma, which was widely spread in the abdomen and metastasized to the colon, liver and distant organs including breast. The treatment is similar to that of primary ovarian cancer. We also reviewed the primary peritoneal cancer metastatic to breast and discuss the possible mechanisms and biology of primary peritoneal cancer, using experimental and animal model.