RT Journal Article
SR Electronic
T1 Esophageal cancer global burden profiles, trends, and contributors
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 20240145
DO 10.20892/j.issn.2095-3941.2024.0145
A1 Teng, Yi
A1 Xia, Changfa
A1 Cao, Maomao
A1 Yang, Fan
A1 Yan, Xinxin
A1 He, Siyi
A1 Cao, Mengdi
A1 Zhang, Shaoli
A1 Li, Qianru
A1 Tan, Nuopei
A1 Wang, Jiachen
A1 Chen, Wanqing
YR 2024
UL http://www.cancerbiomed.org/content/early/2024/07/26/j.issn.2095-3941.2024.0145.abstract
AB Objective: This study aimed to provide a comprehensive overview of the global burden of esophageal cancer (EC) and determine the temporal trends and factors influencing changes in the global burden.Methods: The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022. The mortality and disability-adjusted life years (DALYs) rates for EC from 1990–2019 were sourced from the 2019 Global Burden of Diseases. Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model. The trends in age-related EC burden were assessed using a decomposition approach.Results: An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide. Approximately 75% of cases and deaths occurred in Asia. Nearly 50% of global EC deaths and DALYs were attributed to tobacco use in men in 2019, while 20% were attributed to high body mass index (BMI) in women. From 1990–2019, EC deaths and DALYs attributable to almost all risk factors had declining trends, while EC deaths and DALYs attributed to high BMI in men had upward trends. The age-related EC burden exhibited an upward trend driven by population growth and aging, which contributed to 307.4 thousand deaths and 7.2 million DALYs due to EC.Conclusions: The EC burden remains substantial worldwide. Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC. Population growth and aging pose challenges for EC prevention and control efforts.All data used in this study are publicly available from the Global Cancer Observatory (GCO) [https://gco.iarc.fr] and the Global Burden of Disease Study 2019 [https://vizhub.healthdata.org/gbd-results/].