PT  - JOURNAL ARTICLE
AU  - Tiong, Siaw Sze
AU  - Dickie, Colleen
AU  - Haas, Rick L.
AU  - O’Sullivan, Brian
TI  - The role of radiotherapy in the management of localized soft tissue sarcomas
AID  - 10.20892/j.issn.2095-3941.2016.0028
DP  - 2016 Sep 01
TA  - Cancer Biology and Medicine
PG  - 373--383
VI  - 13
IP  - 3
4099  - http://www.cancerbiomed.org/content/13/3/373.short
4100  - http://www.cancerbiomed.org/content/13/3/373.full
SO  - Cancer Biol Med2016 Sep 01; 13
AB  - The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technology advances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT) and particle therapy will also be discussed.