RT Journal Article
SR Electronic
T1 Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 260
OP 268
DO 10.20892/j.issn.2095-3941.2015.0102
VO 13
IS 2
A1 Zhou, Wen-Ya
A1 Zheng, Hong
A1 Du, Xiao-Ling
A1 Yang, Ji-Long
YR 2016
UL http://www.cancerbiomed.org/content/13/2/260.abstract
AB The fibroblast growth factor receptor (FGFR) family plays important roles in regulating cell growth, proliferation, survival, differentiation and angiogenesis. Deregulation of the FGF/FGFR signaling pathway has been associated with multiple development syndromes and cancers, and thus therapeutic strategies targeting FGFs and FGFR in human cancer are currently being explored. However, few studies on the FGF/FGFR pathway have been conducted in sarcoma, which has a poor outcome with traditional treatments such as surgery, chemotherapy, and radiotherapy. Hence, in the present review, we provide an overview of the role of the FGF/FGFR pathway signal in sarcoma and FGFR inhibitors, which might be new targets for the treatment of sarcomas according to recent research.