PT  - JOURNAL ARTICLE
AU  - Li, Yi
AU  - Wei, Bing
AU  - Xue, Xia
AU  - Li, Hongle
AU  - Li, Jun
TI  - Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis
AID  - 10.20892/j.issn.2095-3941.2023.0177
DP  - 2024 Feb 15
TA  - Cancer Biology & Medicine
PG  - 163--174
VI  - 21
IP  - 2
4099  - http://www.cancerbiomed.org/content/21/2/163.short
4100  - http://www.cancerbiomed.org/content/21/2/163.full
SO  - Cancer Biology & Medicine2024 Feb 15; 21
AB  - Esophageal cancer (EC) is an aggressive malignancy with a poor prognosis. Various factors, including dietary habits, and antacid and antibiotic use, have been shown to influence the esophageal microbiome. Conversely, enrichment and diversity of the esophageal microbiome can also impact its function. Recent studies have revealed prevalent changes in the esophageal microbiome among patients with EC, thus suggesting the potential contribution of the esophageal microbiome to EC development. Additionally, distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy, indicating the role of the esophageal microbiome in modulating treatment outcomes. In this review, we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases, with a focus on identifying microbial communities associated with EC pathogenesis and prognosis. Understanding the role of the microbiome in EC may aid in early detection and optimized treatment strategies, ultimately leading to better outcomes for patients.